SAM-e (S-adenosylmethionine) is a naturally occurring compound found throughout the human body. SAM-e is involved in many important aspects of human function. For example, it plays key roles in your body’s immune system, it helps in the production and the breakdown of several of the chemical that affect the brain such as the breakdown of serotonin and dopamine, and it can also be found in almost all human cells. It works to help maintain the cell membranes.

SAM-e is sold as an over the counter, dietary supplement. It is often made from fermented yeast.

SAM-e is thought to be a main factor in over 30 processes of the human body. When used as a dietary supplement SAM-e can offer many benefits. One of the most recognized therapeutic benefits of SAM-e is its ability to relieve pain that is associated with osteoarthritis.

A number of studies out of Europe and the United States have shown that SAM-e when taken orally can reduce inflammation and can decrease pain that is associated with arthritis. Several short-term studies have even shown that SAM-e can be as effective as taking a non-steroidal anti inflammatory drug. A number of researchers abroad also believe that SAM-e can play a contributing factor in cartilage repair to some degree. Other studies have shown little effect on the pain associated with osteoarthritis.

SAM-e works in combination with B vitamins, specifically with vitamin B12 and B6. When using SAM-e it is important to also supplement with these B vitamins to ensure that you are getting the full benefit of SAM-e.

You should always talk to your doctor before using SAM-e (S-adenosylmethionine) or starting any new supplement regimen. SAM-e (S-adenosylmethionine) carries some side effects, especially if it is taken in high doses. SAM-e can interact with some prescribed medications, specifically with some prescribed antidepressants. It should also not be combined with certain medications. It has also been known to make symptoms of Parkinson’s disease worse.

Consult with your primary care physician to find out if SAM-e (S-adenosylmethionine) is a supplement that can be safely included into your daily routine.