Many natural remedies have been tried or promoted for Migraine Headache but not all of them have been well studied. Co-enzyme Q10 has been studied in clinical trials and proven better than placebo effects in reducing the number and severity of attacks in more than 50% of patients. It appears that the best effects would be achieved in long term use. In Migraine treatment, Prevention is of great importance. CO-ENZYME Q10 has been demonstrated by evidence based medicine as a relatively safe option to be considered for migraine prevention. The studied doses were between 150 mg to 300 mg per day. The effects were seen to start at around 4 weeks. The best effects were noted after 12 weeks of use.