Human’s mind is trained by society to think of I as a different entity than you and the rest of our universe. We are thought to think and feel separate from others and this has led into feelings of loneliness and depression.
By the current understanding of physics all the matter and energy in universe have come from one source billions of years ago and they only change shapes over time.
Dying stars create solid matters that gather by gravity and make planets. Our planet earth is one of them. So the matter in our right hand might have come from a different star than the matter in our left hand, but we are all parts of the same continuity of matter and energy by different shapes and forms. The same way that an ocean wave is not separate from the ocean itself, we are not separate from the rest of our universe.
There is no disconnect and we should not feel isolated at any point. The wave is the ocean and you are the universe.